Charles Dickens sits thoughtfully at a large wooden desk by a window, surrounded by bookshelves and writing materials, with an outdoor scene visible through the glass.
A man in a suit points and speaks animatedly while another man looks serious. Multiple large medical syringes are superimposed over the image in the foreground.

WWTI Doctors, Trump Based Medicine, and the “Vindication” of Andrew Wakefield

Dr. Vinay Prasad seems poised to stop the "too many too soon" approach and start making Andrew Wakefield's dreams a reality.

/ October 31, 2025

Rejecting The Null Hypothesis

In various contexts, for practical, philosophical, and logical reasons, there is a default assumption. In the criminal justice system, for example, someone is presumed innocent until proven guilty. Therefore we must act “as if” someone is innocent until the burden of proof is met that they are indeed guilty of the specific crime of which they are accused. In medicine, if someone...

/ October 29, 2025
Two panels show how PD-L1 on tumor cells binds to PD-1 on T cells to block immune response, and how anti-PD-L1 or anti-PD-1 drugs block this interaction, allowing T cells to kill tumor cells.

The opposite of “turbo cancer”: COVID-19 vaccines sensitize cancer to immunotherapy

A new preliminary study published in Nature suggests that COVID-19 vaccines might actually boost the immune system to make immunotherapy more effective. If confirmed in followup studies, this result suggests that the vaccines do the opposite of causing "turbo cancer."

/ October 27, 2025
Five men in suits sit behind a table with microphones and water bottles. An American flag and a blue government flag are in the background, indicating a formal panel discussion or press conference.

Dr. Vinay Prasad Doesn’t Realize He’s The Establishment. It’s His Job to Produce Results for the American Public, Not Fluff Donald Trump.

Because he can masterfully feign concern over evidence and data, Dr. Prasad is the Shohei Ohtani of spreading doubt and mistrust about vaccines. It's no surprise that under his "leadership", diseases are spreading and Andrew Wakefield is taking a victory lap.

/ October 26, 2025
Former President Donald Trump sits at the Oval Office desk, gesturing with open hands, while two men in suits stand behind him smiling. Flags and official emblems are visible in the background.

Professor Stephen Macedo: How Does it Feel to Have Elevated MAGA/MAHA Propagandists?

The fault is not yours alone. You were just a bit player in a larger misinformation media ecosystem that was devoted to rewriting the history of the pandemic, numbing people to the grave risk We Want Them Infected doctors.

/ October 24, 2025

Opposing Chiropractic Vertebral Subluxation Theory

There is no credible evidence to support use of spinal manipulation to correct vertebral subluxations as a treatment for non-musculoskeletal disorders

/ October 23, 2025
A gloved hand holds a vial labeled "COVID-19 Coronavirus Vaccine" next to a filled syringe, ready for injection. The background is blurred and light-colored.

The Effectiveness of COVID Vaccines

One of the common themes of SBM is that medical evidence can be very complex. In order to come to any robust conclusion about what the science says on any question you need to do a careful and thorough evaluation of all the relevant evidence, including plausibility as well as observational and experimental clinical evidence. Essentially we want to look at the...

/ October 22, 2025
X-ray image showing a detailed front view of a human knee joint, including the femur, tibia, and gap of the joint space. The bones appear intact, with clear outlines visible.

Tylenol Ramblings

This was an extremely difficult post to write. I live in war-ravaged Portland, Oregon, and it is like World War II here. Think Berlin at the end. Nothing but chaos, death and destruction. A burning hell hole. I sit in my cellar, the walls shaking from the brown bombs and artillery. Using the light from the burning house next door to see...

/ October 21, 2025
Casey Means

Surgeon General nominee Dr. Casey Means and functional medicine: Legitimizing quackery

Surgeon general nominee Dr. Casey Means is an advocate of "functional medicine." She, MAHA, and a new "board certification" will falsely legitimize quackery.

/ October 20, 2025