Tag: clinical trials
Gender-Affirming Care is Not Experimental, Part II
A lot of the "facts" about providing healthcare to transgender youth turn out to be not actually facts. We present here a summary of the evidence relating to transition-related health care for transgender adolescents.
Homeopathy and Pre-Registered Trials
Preregistering clinical trials is a great idea, but we have to actually track registration.
Signos Sells a Continuous Glucose Monitor, But Not to Diabetics
Signos is asking customers to pay for the privilege of testing their glucose monitoring system.
How to design high quality acupuncture trials: The Good, The Bad, and The Ugly
Acupuncture advocates have published guidelines for "rigorous" acupuncture randomized controlled trials. While that sounds good on the surface, the devil is in the details, which reveal that the dedication to scientific rigor is perhaps not so strong.
Pfizer’s new COVID-19 protease inhibitor drug is not just “repackaged ivermectin”
Pfizer recently announced that its new protease inhibitor-based drug was 89% effective in preventing hospitalization due to COVID-19 and it is seeking an emergency use authorization for it from the FDA. Antivaxxers claim that ivermectin targets the same protease and is being "suppressed" to protect Pfizer's profits from the new drug. What's the real story? Hint: Antivaxxers took a grain of truth...
What the heck happened to The BMJ?
Last week, The BMJ published an "exposé" by Paul Thacker alleging patient unblinding, data falsification, and other wrongdoing by a company running three sites for the massive clinical trial of the Pfizer COVID-19 vaccine. It was a highly biased story embraced by antivaxxers, with a deceptively framed narrative and claims not placed into proper context, leading me to look into the broader...
To unblind or not to unblind? That is the question about clinical trials of COVID-19 vaccines
Antivaccine alternative health tycoon Joe Mercola claims that the unblinding of participants in the clinical trials of Moderna and Pfizer COVID-19 vaccines was intended to "blow up the trials" and undermine the science, making it impossible ever to identify long term adverse events. What he's really doing is deceptively oversimplifying complex ethical and scientific issues surrounding these trials in the middle of...
Dubious stem cell trials for autism and the darker side of quackademic medicine
Despite a lack of evidence, Duke University is all-in on stem cells for autism, thanks to a billionaire benefactor and a highly dodgy for-profit Panama stem cell clinic. How did this come to be and what will be the outcome? Whatever the answers to these questions, it is clear that arrangements like the one between Duke University and The Stem Cell Institute...
HCQTrial.com: Astroturf and disinformation about hydroxychloroquine and COVID-19 on steroids
Late last week, a "study" published on HCQTrial.com by an anonymous source claiming to be a group of PhD scientists went viral. It claimed that countries that used hydroxychloroquine to treat COVID-19 had a 79% lower fatality rate than those who didn't. It was horrible science and quickly debunked on Twitter by several epidemiologists. That didn't stop it from going viral. Disinformation...
More evidence that acupuncture doesn’t work for chronic pain
Acupuncture is a theatrical placebo whose real history has been retconned beyond recognition. A new systematic review of systematic reviews of acupuncture for chronic pain highlights that conclusion and catalogues the many weaknesses in the design of acupuncture clinical trials.