Category: Clinical Trials

Turmeric for osteoarthritis: Promising but modest effects

A new trial of turmeric (curcumin) for osteoarthritis suggest it may have medicinal effects.

/ September 17, 2020
COVID-19 vs. FDA and CDC

In the age of the COVID-19 pandemic, can we trust the CDC and FDA any more?

Since the COVID-19 pandemic reached the US, increasing concern has been expressed about the politicization of the CDC and FDA due to pressure from the Trump administration to downplay the severity of the pandemic and push out treatments and a vaccine as fast as possible, potentially at the expense of safety. This has led me to a disturbing question: Can I trust...

/ September 14, 2020

Does convalescent plasma work against COVID-19? Who knows?

Last night, the FDA issued an emergency use authorization (EUA) for convalescent plasma to treat COVID-19, even though there are no randomized clinical trials demonstrating efficacy and safety. Does this plasma work? Who knows? But that didn't stop the FDA from issuing the EUA, almost certainly as a result of intense political pressure from the Trump Administration.

/ August 24, 2020
Randomized Controlled Trial Schematic

Dexamethasone and Hydroxychloroquine: Why Randomized Controlled Trials Matter

What does the best evidence tell us about hydroxychloroquine and dexamethasone?

/ August 20, 2020

HCQTrial.com: Astroturf and disinformation about hydroxychloroquine and COVID-19 on steroids

Late last week, a "study" published on HCQTrial.com by an anonymous source claiming to be a group of PhD scientists went viral. It claimed that countries that used hydroxychloroquine to treat COVID-19 had a 79% lower fatality rate than those who didn't. It was horrible science and quickly debunked on Twitter by several epidemiologists. That didn't stop it from going viral. Disinformation...

/ August 10, 2020

Vitamin D supplements do not reduce the risk of depression

A newly-published randomized controlled trial finds vitamin D supplementation has no effect on depression. This adds to the long list of medical conditions for which vitamin D supplementation has turned out to be ineffective.

/ August 6, 2020
Hydroxychloroquine

Hydroxychloroquine to treat COVID-19: Evidence can’t seem to kill it

Despite the accumulating negative evidence showing that hydroxychloroquine doesn't work against COVID-19, activists continue to promote it as a way out of the pandemic. This week, the AAPS and a Yale epidemiologist joined the fray with embarrassingly bad arguments.

/ July 27, 2020

Another Broken Meditation Study

Another study shows meditation does not work, but the authors manage to conclude that it does.

/ July 15, 2020
Pharmacy shelf of priobiotics

Probiotics, revisited

New guidelines do not recommend probiotics for most gastrointestinal conditions.

/ July 9, 2020
Sneeze COVID

Is COVID-19 transmitted by airborne aerosols?

A recurring debate about COVID-19 bubbled up late last week, when a group of scientists announced an as-yet unpublished open letter to the World Health Organization arguing that COVID-19 transmission is airborne and urging it to change its recommendations. What is this debate about, and, if coronavirus is airborne, should we be more scared?

/ July 6, 2020