Category: Clinical Trials
A Desperate Choice
A therapy for brain tumors in young children involves deliberately infecting them with a virus. Scary, and is it worth it?
Statistical Shenanigans?
The manufacturers of Covid-19 vaccines say they are 95% effective. Peter Doshi re-examined the evidence and estimates they are only 19-29% effective. This pre-print of an as-yet unpublished re-analysis raises many questions but doesn't support the claims being made on antivaccine sites.
Apples, Oranges, and How Not to Analyze a Vaccine RCT
The evidence is overwhelming that COVID vaccines keep people alive and out of the hospital. Only someone who starts with the conclusion that vaccines don't work and then works backwards to find the evidence could claim otherwise.
Homeopathy and Pre-Registered Trials
Preregistering clinical trials is a great idea, but we have to actually track registration.
Plenity – A New Weight Loss Pill
Plenity is a new weight loss pill designed to create a sense of fullness. It is backed by a single study where users had an average weight loss of 22 pounds. Not an effective way to achieve ideal weight, but may help some people when combined with diet and exercise.
The “12% efficacy” myth from the “Pfizer data dump”: The latest slasher stat about COVID-19 vaccines
Last week, a claim that Pfizer's own documents demonstrate that the efficacy of its COVID-19 vaccine was only 12% (not the 95% reported) went viral. This is a slasher stat, so-named because it is not new and, like the killers in slasher movie series, even when it appears to be dead it always appears in another installment of the misinformation franchise to...
Pain Reprocessing Therapy
In a trial of Pain Reprocessing Therapy (PRT), 2/3 of patients with chronic low back pain reported significant pain relief with psychotherapy that helped them reconceptualize the pain as nondangerous. Impressive if true, but flaws in research design make the study untrustworthy.
How to design high quality acupuncture trials: The Good, The Bad, and The Ugly
Acupuncture advocates have published guidelines for "rigorous" acupuncture randomized controlled trials. While that sounds good on the surface, the devil is in the details, which reveal that the dedication to scientific rigor is perhaps not so strong.
Science-based medicine isn’t just for CAM. The case of ivermectin shows that it never was.
Another large randomized controlled trial for ivermectin showed no efficacy for the early treatment of COVID-19. This is not a surprise to science-based medicine advocates. Here's why the story of ivermectin shows that SBM isn't just for "complementary and alternative medicine" (CAM) —and never was.
State Attorneys General pursue consumer protection law claims against stem cell clinics
State Attorneys General are pursuing stem cell clinics offering unproven therapies and engaging in fake clinical trials using state consumer protection and false advertising laws, seeking monetary penalties and injunctive relief. Until there is rational, comprehensive stem cell regulation, these actions can help fill the regulatory gap.