Category: Clinical Trials

Statin Side Effects Revisited
Patients on statins frequently report muscle pain and other side effects, but controlled studies have shown side effects are not more frequent than with placebo. Why this discrepancy? A new study sheds some light.

Wim Hof, the Iceman
Wim Hof, the Iceman, is extraordinarily resistant to extreme cold. His Wim Hof Method (WHM) combines breathing exercises, cold exposure, and meditation. Hyperventilation has been shown to reduce the body's response to inflammation, but Hof's extravagant claims of health benefits are not supported by scientific evidence.

Progeria
The first drug to treat Hutchinson-Gilford Progeria, a rare and uniformly fatal rapid aging disease, has been approved by the FDA. It can prolong the life of these children by 2.5 years, but it is very expensive.

Appendicitis: Surgical vs. Medical Treatment
Surgery or antibiotics for appendicitis? This new study can help with the decision.

When Doctors Refuse to Believe Evidence
Paul Offit's new book covers the evidence for many surgeries, medications, and screening tests that have been proven ineffective and harmful yet are still being used by doctors who refuse to follow the science.

Jumping the Gun: Antibody Drugs for Covid-19
Why did the US government promise to buy a product that had failed testing?

Aroma Acupoint Therapy
"Aroma acupoint therapy" demonstrates how the combination of several nonsensical ideas involving essential oils and acupuncture produces, unsurprisingly, yet another nonsensical CAM treatment.

Dubious stem cell trials for autism and the darker side of quackademic medicine
Despite a lack of evidence, Duke University is all-in on stem cells for autism, thanks to a billionaire benefactor and a highly dodgy for-profit Panama stem cell clinic. How did this come to be and what will be the outcome? Whatever the answers to these questions, it is clear that arrangements like the one between Duke University and The Stem Cell Institute...

Ian Harris on “Surgery, the Ultimate Placebo”
Ian Harris explains that more than half of commonly performed surgical operations may be placebos. Adequate studies using a blinded control group are essential.

The Evidence for Hydrogen Water
Alex Tarnava sells Drink HRW Rejuvenation tablets. The evidence for the health benefits of drinking hydrogen water is not convincing.