Results for: Ioannidis+
The life cycle of translational research
I’m a translational researcher. To those of you who aren’t familiar with what that means, it means (I hope) that I study potential therapies in the lab and try to translate them into actual therapies that will cure patients of breast cancer — or, at the very least, improve their odds of survival or prolong survival when cure is not possible. Translational...
Buteyko Breathing Technique – Nothing to Hyperventilate About
A reader recently sent in a link to a New York Times article that discussed an alternative breathing technique developed in Russia for the treatment of asthma called the Buteyko Method, or the Buteyko Breathing Technique (BBT), and asked for an evaluation of the claims on SBM. This post will attempt to be a reasonably comprehensive evaluation of Buteyko and his therapy...
Lithium for ALS – Angioplasty for MS
Peter Lipson reported Monday about new research suggesting that multiple sclerosis may be caused by venous blockage. He correctly characterized some of the hype surrounding this story as “irrational exuberance.” This is a phenomenon all too common in the media – taking the preliminary research of an individual or group (always presented as a maverick) and declaring it a “stunning breakthrough,” combined...
Bibliography for my Talk at TAM 7: Why Evidence-Based Medicine is not yet Science-Based Medicine
As promised at the meeting. Let me know by comment if you think I left anything out.
Does popularity lead to unreliability in scientific research?
One of the major themes here on the Science-Based Medicine (SBM) blog has been about one major shortcoming of the more commonly used evidence-based medicine paradigm (EBM) that has been in ascendance as the preferred method of evaluating clinical evidence. Specifically, as Kim Atwood (1, 2, 3, 4, 5, 6, 7, 8) has pointed out before, EBM values clinical studies above all...
Cancer research: Going for the bunt versus swinging for the fences
A couple of weeks ago, our resident skeptical medical student Tim Kreider wrote an excellent article about an op-ed in NEWSWEEK by science correspondent Sharon Begley, in which he pointed out many misconceptions she had regarding basic science versus translational research, journal impact factors, and how journals actually determine what they will publish. Basically, her thesis rested on little more than a...
Human subjects protections and research ethics: Where the rubber hits the road for science-based medicine
Although clinical trials are science, they often can't be controlled as well as experiments in most branches of science. The reason is that the experimental subjects are human, and ethics demands that risks and harms be minimized and benefits maximized.
Bad Books
In the interests of fairness and intellectual honesty, I’ve forced myself to read a lot of really bad books. The True Believer tells me his guru’s book is the Real Stuff. He tells me I have a closed mind and won’t look at anything outside establishment dogma, and if I only read the book and understood Dr. Quack’s evidence and arguments, I...
Fakin’ it
Last week the Times of London revealed inside information from the General Medical Council (UK, responsible for physician licensing) of an ongoing investigation of Dr. Andrew Wakefield and from its own investigation. This revelation recalled other instances of fakery from reports of sectarian medicine (“CAM”) successes. The Medical Council information contained evidence that the data from the now famous Wakefield cases used to...
On the dangers of using valid placebo controls in clinical trials of acupuncture
I don’t recall if I’ve ever mentioned this before on this blog, but there was a time when I was less skeptical of acupuncture than I am now. It’s true. Don’t get me wrong, though. I never for a minute considered that the whole rigamarole about “unblocking” or “redirecting” the flow of that mystical life force known as qi had anything to...