As promised at the meeting. Let me know by comment if you think I left anything out.

 Intro to EBM.

Examples of prior knowledge having been insufficient to determine safety and efficacy.

  • Echt DS, Liebson PR, Mitchell LB, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo — the Cardiac Arrhythmia Suppression Trial. N Engl J Med 1991;324:781-788. [Abstract]
  • Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women’s Health Initiative Randomized Controlled Trial. Writing Group for the Women’s Health Initiative Investigators. JAMA. 2002;288(3):321-333. Available at:

Reasonable Cochrane Review (abstract).

Misleading Cochrane Reviews—due to failure to acknowledge the necessary role of prior knowledge (abstracts).

Laetrile; Ernst’s curious view of prior knowledge.

Misleading reviews from Natural Standard and Harvard Medical School.

Homeopathy: the Evidence.

Prior Probability and Bayes Theorem.

Misleading Trials.

Misleading Meta-analysis and systematic review.



Posted by Kimball Atwood