The Debate About Off-Label Prescriptions
So-called off-label uses of prescription drugs is an enduring controversy – probably because it involves a trade-off of competing value judgments.The FDA is considering loosening its monitoring of off-label prescriptions, but critics are charging that, if anything, regulations should be tightened. Many issues of science-based medicine are at the core of this controversy. In the US the FDA (Food and Drug Administration)...
Statins Are Better on JUPITER
Over 26 million Americans are taking statin drugs. Some people think they should be available over-the-counter without a prescription, and it has even been facetiously suggested that they should be added to our drinking water. The protective effect of statins in cardiovascular disease and in high-risk patients with high cholesterol levels is well established. But what about people with no heart disease...
Does alternative medicine have alternative ethics?
Kimball Atwood has an interesting series of posts on the ethics of alternative medicine which I strongly encourage you to read. He does a great job examining the ethical implications of certain alternative medicine practices, and has a terrific dialog with Peter Moran, a frequent commenter here. At my other online locale, I make frequent forays into the morass of medical...
Robert F. Kennedy, Jr., vaccines, the EPA, and the interface with science-based medicine and public policy
This blog is entitled Science-Based Medicine for a reason, and that’s because we here at SBM believe that the best method to result in the most efficacious treatments for the most people is through the application of science to the evaluation of the biology, pathophysiology, and treatment of disease and disorders. I may (or may not) be departing a bit from the...
“It’s just a theory”
I am afraid that the experiments you quote, M. Pasteur, will turn against you. The world into which you wish to take us is really too fantastic. La Presse, 1860 It’s just a theory. Not evolution. Germ theory. Just a theory, one of many that account for the etiology of diseases. I should mention my bias up front. I am, as some...
Breast cancer and migraines–what is risk, anyway?
One of the questions most often asked in the medical literature is “what is the risk of x?” It’s a pretty important question. I’d like to be able to tell my patient with high blood pressure what their risk of heart attack is, both with and without treatment. And risk is a sexy topic—the press loves it. Whether it’s cell phones and...
Wyeth vs. Levine: Should Drug Label Standards Be Determined By Juries?
It is with some degree of trepidation that I enter the fray on the Wyeth vs. Levine case. I’ve been watching the media frenzy about the lawsuit with interest – mostly because (for the first time in a while) I think that the pharmaceutical company is in the right on this one – and that most journalists (and even medical journal editors)...
Rainman – Link Between Precipitation and Autism
A new study published in the Archives of Pediatrics and Adolescent Medicine shows a positive correlation between counties in California, Oregon, and Washington with greater precipitation and a higher incidence of autism. While the results of this study are interesting, it needs to be put into proper context. Also of note, the authors had presented early results from this data previously. Correlation...
Why we don’t prescribe bark for cancer
My valued colleague, Dr. Antonio Baines, recently invited me to speak for his graduate course in Toxicology. Dr. Baines’ course is one of the most highly-regarded graduate classes at North Carolina Central University for M.S. students in Biology and Pharmaceutical Sciences. Antonio asked that I discuss the pharmacology and toxicology of herbal and non-botanical dietary supplements but pretty much gave me free...
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November 4, 2008
Circumcision: What Does Science Say?
There are no compelling scientific arguments for or against neonatal circumcision. Benefits and risks are, scientifically speaking, small. However, the nonscientific arguments for and against circumcision are loud, and often irrational.