Category: Clinical Trials

HCQTrial.com: Astroturf and disinformation about hydroxychloroquine and COVID-19 on steroids

Late last week, a "study" published on HCQTrial.com by an anonymous source claiming to be a group of PhD scientists went viral. It claimed that countries that used hydroxychloroquine to treat COVID-19 had a 79% lower fatality rate than those who didn't. It was horrible science and quickly debunked on Twitter by several epidemiologists. That didn't stop it from going viral. Disinformation...

/ August 10, 2020

Vitamin D supplements do not reduce the risk of depression

A newly-published randomized controlled trial finds vitamin D supplementation has no effect on depression. This adds to the long list of medical conditions for which vitamin D supplementation has turned out to be ineffective.

/ August 6, 2020
Hydroxychloroquine

Hydroxychloroquine to treat COVID-19: Evidence can’t seem to kill it

Despite the accumulating negative evidence showing that hydroxychloroquine doesn't work against COVID-19, activists continue to promote it as a way out of the pandemic. This week, the AAPS and a Yale epidemiologist joined the fray with embarrassingly bad arguments.

/ July 27, 2020

Another Broken Meditation Study

Another study shows meditation does not work, but the authors manage to conclude that it does.

/ July 15, 2020
Pharmacy shelf of priobiotics

Probiotics, revisited

New guidelines do not recommend probiotics for most gastrointestinal conditions.

/ July 9, 2020
Sneeze COVID

Is COVID-19 transmitted by airborne aerosols?

A recurring debate about COVID-19 bubbled up late last week, when a group of scientists announced an as-yet unpublished open letter to the World Health Organization arguing that COVID-19 transmission is airborne and urging it to change its recommendations. What is this debate about, and, if coronavirus is airborne, should we be more scared?

/ July 6, 2020

New Drugs for Sickle Cell Disease: Small Benefit, Large Price

The FDA has approved two new drugs to treat sickle cell disease. They don’t do much, and they are prohibitively expensive.

/ June 30, 2020

Do face masks decrease the risk of COVID-19 transmission?

As wearing masks to prevent the spread of COVID-19 becomes a culture war issue, the evidence for whether they prevent transmission of COVID-19 remains contested. A new systematic review and meta-analysis provides the best evidence yet that social distancing and masks are highly effective at decreasing the risk of contracting coronavirus, while eye protection might also help, but it's not a slam...

/ June 8, 2020
COVID-19

COVID-19: Out-of-control science and bypassing science-based medicine

During the COVID-19 pandemic, there hasn't just been a pandemic of coronavirus-caused disease. There's also a pandemic of misinformation and bad science. It turns out that doctors today are just as prone as doctors 100 years ago during the 1918-19 influenza pandemic to bypass science-based medicine in their desperation to treat patients.

/ May 4, 2020
Hydroxychloroquine

Hydroxychloroquine and the price of abandoning of science- and evidence-based medicine

Based on anecdotal evidence early in the pandemic and then-unreported clinical trials, followed by hype and bad studies by French "brave maverick doctor" Didier Raoult, antimalarial drugs hydroxychloroquine and chloroquine became the de facto standard of care for COVID-19, despite no rigorous evidence that they worked. A steady drip-drip-drip of negative studies has led doctors and health authorities to rethink and backtrack,...

/ April 27, 2020