Category: Clinical Trials
Are placebo effects genetically determined?
We frequently write about placebo effects here at SBM because understanding placebo effects is essential to understanding a lot of clinical trial science and, most relevant to the topics of this blog, how those promoting unscientific medicine misunderstand and misuse placebo effects to promote quackery. Last week, The NYT published an article asking if placebo effects are genetically determined. The evidence supporting...
A Nuanced View on Breast vs Formula
While there is strong evidence that breast is best, a new study suggests that the benefits have been overstated, and may be mostly due to non-specific factors such as better education and overall health care.
Acupuncture versus breast cancer treatment-induced joint pain: Spinning another essentially negative study
The investigators behind a recent clinical trial testing acupuncture to treat joint pain caused by aromatase inhibitors used to treat breast cancer are spinning it as a positive study. As is usually the case for acupuncture studies. It isn't
Bouffant caps versus skull caps in the operating room: A no holds barred cage match
Over the last few years, AORN and the American College of Surgeons have been battling it out over AORN's 2014 guideline that has increasingly led to the banning of the surgical skull cap in the operating room in favor of the bouffant cap. Lacking from this kerfuffle has been much in the way of evidence to support AORN's guideline, but unfortunately that...
Clínica 0-19: False hope in Monterrey for brain cancer patients (part 3)
This is the conclusion of my series on Clínica 0-19, the cancer clinic where Drs. Alberto Siller and Alberto Garcia see patients with DIPG, a deadly brain tumor, whom they treat at Hospital Angeles in Monterrey Mexico with an unproven combination of intra-arterial chemotherapy with up to 11 drugs and a poorly defined dendritic cell immunotherapy. Some people have asked me: What's...
Clínica 0-19: False hope in Monterrey for DIPG patients (part 1)
Drs. Alberto Siller and Alberto Garcia run Clínica 0-19 in Monterrey, Mexico, which has become a magnet for patients with diffuse intrinsic pontine glioma (DIPG), a deadly brain cancer. Unfortunately, their treatment is an unproven combination of 11 chemotherapy drugs injected into an artery feeding the brainstem, plus an unknown and unproven "immunotherapy." Of course it all costs $300,000 or more for...
Prevagen goes P-hacking
Can post-hoc data-dredging produce competent and reliable scientific evidence for Prevagen's claims of memory improvement? The FTC and consumer groups say "no."
So-Called Alternative Medicine
Edzard Ernst calls it "So-Called Alternative Medicine". This insider's view of SCAM is a new book from an prolific researcher and author.
Are generic drugs equivalent to brand-name drugs?
Generic drugs cost a fraction of brand-name drugs. What gives us confidence they are equivalent? Science.
Vertigo Voodoo: A Crazy-Sounding Cure That Actually Works
A sequence of positional changes sounds like voodoo, but is actually an effective way to cure benign paroxysmal positional vertigo (BPPV).