Tag: randomized clinical trial
Donald Trump bragged that “right-to-try” has saved thousands of lives. It hasn’t.
Former President Donald Trump bragged in his acceptance speech at the Republican National Convention that "right-to-try" had saved "thousands of lives"? What's the real story? (Hint: Nowhere near that.)
Why Are Sensible Medicine Doctors Indifferent to the Nonsense Comments of Sensible Medicine Commentators? As Instructed, I Consider the Dualities of Interest and Motivating Biases.
Sensible Medicine doctors often utter the words "do an RCT". So why are their readers so ignorant about RCTs?
RFK Jr. resurrects an old antivax half-truth about “saline placebos” in randomized controlled trials of vaccines
Robert F. Kennedy, Jr. has resurrected the antivax claim that the childhood vaccine schedule has never been tested in randomized controlled trials (RCTs) with a saline placebo controls (and therefore the vaccine schedule is unsafe). This is an old and deceptive antivax half-truth that ignores both what constitutes a scientifically valid placebo and the ethical requirements for RCTs.
The Cochrane mask fiasco: How the evidence-based medicine paradigm can produce misleading results
Last week, the Cochrane Collaborative was forced to walk back the conclusions of a review by Tom Jefferson et al that had been spun in the media as proving that "masks don't work." Tom Jefferson himself has been problematic about vaccines for a long time, but the rot goes deeper. What is it about the evidence-based medicine paradigm that results in misleading...
Science-based medicine isn’t just for CAM. The case of ivermectin shows that it never was.
Another large randomized controlled trial for ivermectin showed no efficacy for the early treatment of COVID-19. This is not a surprise to science-based medicine advocates. Here's why the story of ivermectin shows that SBM isn't just for "complementary and alternative medicine" (CAM) —and never was.
Ivermectin: The acupuncture of COVID-19 treatments
As high-quality evidence increasingly and resoundingly shows that ivermectin does not work against COVID-19, advocates are doing what acupuncture advocates do: Turning to lower quality "positive" studies to claim incorrectly that their favorite ineffective treatment actually does "work".
A New Study Finds No Benefit from Chiropractic for Infant Colic, but They’ll Keep Doing it Anyway
A new study attempted to answer the question of chiropractic's potential benefit for infant colic. It was successful, but I don't think it turned out the way the authors' hoped. Sadly, I don't think that this will change the mind of any chiropractor who treats babies.
To unblind or not to unblind? That is the question about clinical trials of COVID-19 vaccines
Antivaccine alternative health tycoon Joe Mercola claims that the unblinding of participants in the clinical trials of Moderna and Pfizer COVID-19 vaccines was intended to "blow up the trials" and undermine the science, making it impossible ever to identify long term adverse events. What he's really doing is deceptively oversimplifying complex ethical and scientific issues surrounding these trials in the middle of...
Vitamin D shows no efficacy against moderate to severe COVID-19 infections
A new trial failed to find evidence that a massive dose of vitamin D improves outcomes in patients with moderate to severe COVID-19 infections.
Overtreating the thyroid
For decades there's been debate about whether thyroid medication is necessary for a mild form of thyroid dysfunction. A new trial helps answer that question.