Category: Clinical Trials
New evidence, same conclusion: Tamiflu only modestly useful for influenza
Does Tamiflu have any meaningful effects on the prevention or treatment of influenza? Considering the drug’s been on the market for almost 15 years, and is widely used, you should expect this question has been answered after 15 flu seasons. Answering this question from a science-based perspective requires three steps: Consider prior probability, be systematic in the approach, and get all the...
Stanislaw Burzynski’s propaganda victory on antineoplastons: The FDA caves
Sadly, it looks as though Stanislaw Burzynski is going to win his latest round with the FDA. Same as it ever was.
“Right to try” laws and Dallas Buyers’ Club: Great movie, terrible for patients and terrible policy
"Right-to-try" is a new kind of bill that claims to give terminally ill patients the "right to try" experimental therapeutics that have passed phase 1 testing. It's a smokescreen, no more real than the movie that seemingly inspired it.
Acupuncture Vignettes
I seem to be writing a lot about acupuncture of late. As perhaps the most popular pseudo-medicine, there seems to be more published on the topic. I have a lot of internet searches set up to automatically feed me new information on various SCAMs. Interestingly, all the chiropractic updates seem to be published on chiropractic economics sites, not from scientific sources. Go...
The illusions of “right to try” laws
[Ed. Note: For additional commentary on why “right-to-try” laws are such a bad idea, see “Right to try” laws and Dallas Buyers’ Club: Great movie, terrible for patients and terrible policy and The false hope of “right-to-try” metastasizes to Michigan.] There is nothing like a touching anecdote to spur a politician into action. And those who want to try investigational drugs outside...
Eric Merola and Ralph Moss try to exhume the rotting corpse of Laetrile in a new movie
Note: Some of you have probably seen a different version of this post fairly recently. I have a grant deadline this week and just didn’t have time to come up with fresh material up to the standards of SBM. This left me with two choices: Post a “rerun” of an old post, or recycle something. I decided to recycle something for reasons...
The Canadian National Breast Screening Study ignites a new round in the mammography wars
The last couple of weeks, I’ve made allusions to the “Bat Signal” (or, as I called it, the “Cancer Signal,” although that’s a horrible name and I need to think of a better one). Basically, when the Bat Cancer Signal goes up (hey, I like that one better, but do bats get cancer?), it means that a study or story has hit...
The Pollyanna Phenomenon and Non-Inferiority: How Our Experience (and Research) Can Lead to Poor Treatment Choices
Pollyanna, a popular children’s book written in 1913 by Eleanor H. Porter, introduced the world to one of the most optimistic fictional characters ever created. She always saw the good in people and her approach to life frequently involved playing “The Glad Game”, where she attempted to find something to appreciate in every situation no matter how unfortunate. She was glad about...
The return of the revenge of high dose vitamin C for cancer
Vitamin C is back in the news as a cancer cure. Is it? No, no it is not.
Treating Pain Psychologically
One of the goals of rigorous science is to disentangle various causes so we can establish exactly where the lines of cause and effect are. In medicine this allows us to then optimize the real causes (what aspect of treatments actually work) and eliminate anything unnecessary. Eliminating the unnecessary is more than just about efficiency – every intervention in medicine has a...