Tag: depression

One reason mouse studies often don’t translate to humans very well

Mouse models are often used as preclinical models of human disease, but the number of drugs that succeed in mice but go on to be approved as a drug for humans is only about one in ten. A new study comparing gene expression in the cells of human brains with those of mouse brains provides new insight into why.

/ August 26, 2019

Zapping Antipsychiatry ECT Nonsense

These days people's perceptions of electroconvulsive therapy have a fictionalized understanding of what it is, and its harms. The reality is quite different.

/ July 25, 2019

The Pseudoscience of Kelly Brogan

Kelly Brogan sells an impressive array of pseudoscience wrapped in the standard alternative tropes.

/ September 19, 2018

St. John’s Wort for depression – A herbal remedy that works?

St. John's wort is a herbal remedy that appears to be effective for the treatment of depression. But how does it compare to antidepressants?

/ April 5, 2018

The Debate Is Over: Antidepressants DO Work Better Than Placebo

The idea that antidepressants are no more effective than placebo has been put to rest. They clearly work when used appropriately, although the effect size is not as large as the published studies have suggested.

/ March 6, 2018

Corrigendum. The Week in Review for 02/19/2017

More poorly done acupuncture studies. Burzynski eats just desserts. Italians like homeopathy. New Jersey is going after Oregon. And more

/ February 19, 2017

Should you try a “natural alternative” before medication?

The idea of taking medication can be frightening. And as consumers and patients that want to make our own informed health decisions, it’s understandable and even appropriate to question our physicians when they recommend drug treatments. We need to understand the rationale for any medication that’s recommended or prescribed, the benefits of therapy, the side effects, and if there are any other...

/ July 14, 2016

Antidepressants and Autism

A new study looking at the correlation of antidepressant use during pregnancy and the development of autism spectrum disorder (ASD) has been making headlines. While the results are likely significant, they are not as worrisome as the headlines may suggest. The study: strengths and weaknesses Overall the study design is solid. They followed 145,456 singleton full-term infants for a total of 904,035.50...

/ December 16, 2015

Acupuncture Odds and Ends

I’m cheating. No, I’m recycling. ‘Tis the season to have to no time to get anything done. Since I know none of you pay attention to the blog of at the Society for Science-Based Medicine and I have no time with work and the holidays to come up with new material, I am going to collect and expand on the entries on...

/ December 26, 2014

Depression Re-examined: A New Way to Look at an Old Puzzle

Depression affects approximately 10% of Americans. It can be fatal; I found estimates of suicide rates ranging from 2-15% of patients with major depression. When it doesn’t kill, it impairs functioning and can make life almost unbearably miserable. It is a frustrating condition because there is no lab test to diagnose it, no good explanation of its cause, and the treatments are...

/ February 25, 2014