Category: Clinical Trials
Dr. Stanislaw Burzynski’s antineoplastons versus patients
Prelude: Doin’ the Antineoplaston Boogaloo with Eric Merola and Stanislaw Burzynski In December I noted that Eric Merola, the “film maker” (and, given the quality of his work, I do use that term loosely) who was responsible for a movie that was such blatant propaganda that it would make Leni Riefenstahl blush were she still alive (Burzynski The Movie: Cancer Is Serious...
Rituximab for Chronic Fatigue Syndrome: Jumping the Gun
Now that the XMRV myth has been put to rest, patients with Chronic Fatigue Syndrome (CFS) are no longer jumping the gun to demand anti-retroviral treatments. But they are jumping the gun in new ways, based on very preliminary data coming out of Norway. A correspondent in Norway wrote to tell me patients from Norway with myalgic encephalitis/chronic fatigue syndrome (ME/CFS) are travelling...
The Great and Powerful Oz versus science and research ethics
Dr. Mehmet Oz conducted a (poor-quality) clinical trial of green coffee beans for weight loss. Somehow between taping his show and being a doctor, he forgot to get institutional review board approval for ethics. Oops!
Dr. Oz Doubles Down on Green Coffee Bean with a Made-for-TV Clinical Trial
“One of the most important discoveries I believe we’ve made that will help you burn fat – green coffee bean extract” – Dr. Oz, September 10, 2012, Episode “The Fat Burner that Works” Dr. Mehmet Oz may be biggest purveyor of health pseudoscience on television today. How he came to earn this title is a bit baffling, if you look at his...
Isagenix Study Is Not Convincing
Isagenix is a wellness system sold by multilevel marketing. It consists of a suite of products to be used in various combinations for “nutritional cleansing,” detoxification, and supplementation to aid in weight loss, improve energy and performance, and support healthy aging. It allegedly burns fat while supporting lean muscle, maintains healthy cholesterol levels, supports telomeres, improves resistance to illness, reduces cravings, improves...
The NIH funding process according to John Ioannidis: “Conformity” and “mediocrity”?
John Ioannidis published a paper that concluded that the NIH study section process prioritizes "safe" science and "conformity." Is he correct, or is this an exaggeration that uses a view of science that "brave mavericks" advance science far more rapidly than teams collaborating to make incremental progress?
What does a new drug cost? Part II: The productivity problem
A few weeks ago I reviewed Ben Goldacre’s new book, Bad Pharma, an examination of the pharmaceutical industry, and more broadly, of the way new drugs are discovered, developed and brought to market. As I have noted before, despite the very different health systems that exist around the world, we all rely on private, for-profit, pharmaceutical companies to supply drug products and...
Now that Burzynski has gotten off in 2012, Burzynski The Movie will spawn a sequel in 2013
About a year ago, I became interested in a physician named Stanislaw Burzynski who has been treating cancer with compounds that he calls “antineoplastons” for over three decades without, in my opinion, ever having ever produced any compelling evidence that antineoplastons have significant anticancer activity. Although I had been vaguely aware of Burzynski and his activities, it was the first time that...
Journal of Clinical Oncology editorial: “Compelling” evidence acupuncture “may be” effective for cancer related fatigue
Journal of Clinical Oncology (JCO) is a high impact journal (JIF > 16) that advertises itself as a “must read” for oncologists. Some cutting edge RCTs evaluating chemo and hormonal therapies have appeared there. But a past blog post gave dramatic examples of pseudoscience and plain nonsense to be found in JCO concerning psychoneuroimmunology (PNI) and, increasingly, integrative medicine and even integrations...
Ecstasy for PTSD: Not Ready for Prime Time
Hundreds of desperate combat veterans with Post-Traumatic Stress Disorder (PTSD) are reportedly seeking experimental treatment with an illegal drug from a husband-wife team in South Carolina. The Bonhoefers recently published a study showing that adding MDMA (ecstasy, the party drug) to psychotherapy was effective in eliminating or greatly reducing the symptoms of refractory PTSD. It was widely covered in the media, for...