Category: Clinical Trials
Postmodernist attacks on science-based medicine
The postmodernist critique of science consists of two interrelated arguments, epistemological and ideological. Both are based on subjectivity. First, because of the subjectivity of the human object, anthropology, according to the epistemological argument cannot be a science; and in any event the subjectivity of the human subject precludes the possibility of science discovering objective truth. Second, since objectivity is an illusion, science...
The worst of times for antivaccine believers: Yet another study fails to show any link between the MMR vaccine and autism
THE BEST OF TIMES It was the best of times (for antivaccinationists). It was the worst of times (for antivaccinationists). It was the age of wisdom (definitely not for antivaccinationists). It was the age of foolishness (definitely for antivaccinationists). It was the epoch of belief (for antivaccinationists). Such is the time we live in, my apologies to Charles Dickens, even though he...
The Importance and Limitations of Peer-Review
Peer-review is a critical part of the functioning of the scientific community, of quality control, and the self corrective nature of science. But it is no panacea. It is helpful to understand what it is, and what it isn’t, its uses and abuses. Overview When the statement is made that research is “peer-reviewed” this is usually meant to refer to the fact...
Threats to science-based medicine: When clinical trials for new drugs are designed by the marketing division
When the marketing division designs clinical trials, scientific medicine loses.
High dose vitamin C and cancer: Has Linus Pauling been vindicated?
Treating cancer with high-doses of vitamin C is a zombie idea that began with Linus Pauling, and has failed to die ever since. But has new research vindicated this idea? No. No in any meaningful way. This work is the very definition of a long run for a short slide.
The Orange Man
Alternative medicine is not harmless, and carrots cannot cure cancer.
Sterile Water Injections for Pain Relief
Before ethical standards changed, doctors used to occasionally fool patients with placebo injections of sterile saline or water. If my obstetrician had tried to give me sterile water instead of an epidural, I probably would have hit him. But apparently women are getting sterile water injections for childbirth and are telling us they work. What’s going on? A recent study in Sweden...
HIV Treatment Extends Life Expectancy
People with HIV are living longer on the latest anti-retroviral therapy. This is something any infectious disease specialist knows from their own clinical experience – but it’s reassuring (I would even argue necessary) to have objective data to support experience. A study published in the latest issue of Lancet provides this objective data. (Lancet. 2008 Jul 26;372(9635):293-9.) The press release from Bristol...
Cavalcade of Quackery: A Pantomine Horse
Last week I received the news release below that Steve Zeitzew, an orthopedic surgeon at VA Hospital Los Angeles and UCLA, sent to the Healthfraud list. It was sent to me by our colleague Liz Woeckner, President of the nonprofit research protection advocacy organization Citizens for Responsible Care in Research (CIRCARE) http://www.circare.org/ Ms. Woeckner sent it on with a cryptic comment, wondering...
Should We Study Chelation for Autism?
The National Institute of Mental Health (NIMH) supports doing a study on the effects of oral chelation therapy in autism. The proposal is highly controversial, is drawing criticism from many scientists, but has popular support among parents who believe this type of therapy might help their children with autism. The proposal raises many questions about the ethics of biomedical research. Chelation and...