ORBITA: Another clinical trial demonstrating the need for sham controls in surgical trials
Last week, the results of ORBITA were published. This clinical trial tested coronary angioplasty and stenting versus optimal medical management in patients with single-vessel coronary artery disease. It was a resoundingly negative trial, meaning that adding stenting to drug management didn't result in detectable clinical improvement. What was distinctive about this trial is that it used a sham procedure (i.e., placebo) control,...
Torturing mice, data, and figures in the name of antivaccine pseudoscience
In September, antivaccine "researchers" Christopher Shaw and Lucija Tomljenovic published a study claiming to link aluminum adjuvants in vaccines to neuroinflammation and autism. Naturally, the antivaccine movement pointed to it as slam dunk evidence that vaccines cause autism. It's not. In fact, not only is it bad science, but it might well be fraudulent.
UC-Irvine, integrative medicine, and the delusion of being “science-based”
Last month, a billionaire couple, Susan and Henry Samueli, announced a $200 million gift to UC-Irvine to found the Susan and Henry Samueli College of Health Sciences, which will be devoted to integrative medicine and studying "unconventional" treatments. Its founders promise that it will be rigorously science-based in articles in a large, glossy magazine. There are many reasons for doubts about this...
Integrative medicine advocates react to criticisms of the Samuelis’ $200 million gift to UC-Irvine
Last month, Susan and Henry Samueli donated $200 million to the University of California, Irvine to promote integrative medicine. We were pleasantly surprised by the unflattering coverage in the press of the gift. We were unpleasantly unsurprised by the reaction of integrative medicine advocates to the criticism.
Don’t drink your bath water – Epsom salts, liver damage, and naturopaths
What's the harm of naturopathy? How about Epsom salt-induced liver damage?
The Pathological Optimist: More hagiography than documentary about Andrew Wakefield
The Pathological Optimist is a recently released documentary by Miranda Bailey about Andrew Wakefield that I got a chance to see. In interviews and in the film's promotional materials, Bailey takes great pains to emphasize that she "doesn't take a side" about Wakefield. Unfortunately, her film demonstrates that, when it comes to pseudoscience, "not taking a side" is taking a side, and...
Rigvir strikes back, or: A conversation with a Rigvir flack
My skeptical analysis of Rigvir, a "Virotherapy" from Latvia being promoted by alternative medicine clinics as a cancer cure, caught the attention of the International Virotherapy Center (IVC). The result was a long and very telling e-mail exchange between its Assistant of Business Development and myself. I post it because the arguments used in the discussion are very telling about where the...
Ty Bollinger’s “The Truth About Cancer” and the unethical marketing of the unproven cancer virotherapy Rigvir
Last week, I wrote about Rigvir, a "virotherapy" promoted by the International Virotherapy Center (IVC) in Latvia, which did not like what I had to say. When a representative called me to task for referring to the marketing of Rigvir using patient testimonials as irresponsbile, it prompted me to look at how Ty Bollinger's The Truth About Cancer series promoted Rigvir through...
Rigvir: Another unproven and dubious cancer therapy to be avoided
Recently, the Hope4Cancer Institute, a quack clinic in Mexico, has added a treatment known as Rigvir to its coffee enemas and other offerings. But what is Rigvir? It turns out that it's an import from Latvia with a mysterious history. Proponents claim that it is an oncolytic virus that targets cancer specifically and leaves normal cells alone. Unfortunately, there is a profound...
The influenza vaccine and miscarriages: Much ado about nothing
A study published on Wednesday claims to have found a link between influenza vaccination and miscarriage, and antivaxers are gloating. The study itself suffers mightily from post hoc subgroup analyses on small numbers, so much so that even its authors don’t really believe its results. None of that stopped them from publishing the study, thus justifying "more research" that will almost certainly...