Tag: randomized controlled trials
The Cochrane mask fiasco: How the evidence-based medicine paradigm can produce misleading results
Last week, the Cochrane Collaborative was forced to walk back the conclusions of a review by Tom Jefferson et al that had been spun in the media as proving that "masks don't work." Tom Jefferson himself has been problematic about vaccines for a long time, but the rot goes deeper. What is it about the evidence-based medicine paradigm that results in misleading...
Peer review fail: Vaccine publishes antivax propaganda disguised as “reanalyses” of Pfizer and Moderna COVID-19 vaccine clinical trial data
In order portray COVID-19 vaccines as dangerous, Peter Doshi has now managed to get poorly designed and performed "reanalyses" of the clinical trial data used by the FDA to grant emergency use approval of the Pfizer and Moderna vaccines published in two reputable journals, The BMJ and Vaccine? What happened?
Methodolatry and COVID
Doctors who call for an RCT for everything generally haven't run a single RCT on anything. Why is this?
Science-based medicine isn’t just for CAM. The case of ivermectin shows that it never was.
Another large randomized controlled trial for ivermectin showed no efficacy for the early treatment of COVID-19. This is not a surprise to science-based medicine advocates. Here's why the story of ivermectin shows that SBM isn't just for "complementary and alternative medicine" (CAM) —and never was.
Ivermectin: The acupuncture of COVID-19 treatments
As high-quality evidence increasingly and resoundingly shows that ivermectin does not work against COVID-19, advocates are doing what acupuncture advocates do: Turning to lower quality "positive" studies to claim incorrectly that their favorite ineffective treatment actually does "work".
The Yoga RCT
Back in December, 2020, Chief Scientist for the WHO Dr. Soumya Swaminathan tweeted about a study that suggested yoga helped improve various blood markers in people with diabetes. However, a major flaw prevents the study from being rigorous enough to believe its conclusions.
Ian Harris on “Surgery, the Ultimate Placebo”
Ian Harris explains that more than half of commonly performed surgical operations may be placebos. Adequate studies using a blinded control group are essential.
Vitamin D supplements do not reduce the risk of depression
A newly-published randomized controlled trial finds vitamin D supplementation has no effect on depression. This adds to the long list of medical conditions for which vitamin D supplementation has turned out to be ineffective.
An Alternative to Appendectomy: Antibiotics
My title doesn’t refer to alternative medicine, it refers to an alternative within medicine: treating appendicitis with antibiotics instead of surgery. You may be surprised to learn that patients with appendicitis don’t always automatically need an appendectomy. A recent randomized controlled trial in Finland compared surgery to medical treatment. History of appendicitis treatment There is an excellent, detailed history of appendicitis available...
Should placebos be used in randomized controlled trials of surgical interventions?
Trials of new experimental drugs frequently compare them to placebo, particularly when there is a large subjective component to the disease being treated, such as pain. In contrast, placebo-controlled trials are rarely undertaken in surgery, mainly because it's been considered ethically dicey to do sham surgery on one group. Should this change? Should we be more open to doing randomized, placebo-controlled surgery...