Tag: randomized controlled trials

EBM hierarchy

2023: The year that the evidence-based medicine (EBM) paradigm was weaponized against vaccines and public health

Evidence-based medicine (EBM) has been a very useful paradigm for assessing evidence in medicine. However, like any other framework, it can be misused, particularly when fundamentalist EBM methodolatry leads to its inappropriate application to questions for which it is ill-suited, a misuse that has been weaponized against public health during the pandemic.

/ January 1, 2024
Cochrane Collaborative

The Cochrane mask fiasco: How the evidence-based medicine paradigm can produce misleading results

Last week, the Cochrane Collaborative was forced to walk back the conclusions of a review by Tom Jefferson et al that had been spun in the media as proving that "masks don't work." Tom Jefferson himself has been problematic about vaccines for a long time, but the rot goes deeper. What is it about the evidence-based medicine paradigm that results in misleading...

/ March 13, 2023
SARS-CoV-2

Peer review fail: Vaccine publishes antivax propaganda disguised as “reanalyses” of Pfizer and Moderna COVID-19 vaccine clinical trial data

In order portray COVID-19 vaccines as dangerous, Peter Doshi has now managed to get poorly designed and performed "reanalyses" of the clinical trial data used by the FDA to grant emergency use approval of the Pfizer and Moderna vaccines published in two reputable journals, The BMJ and Vaccine? What happened?

/ September 5, 2022

Methodolatry and COVID

Doctors who call for an RCT for everything generally haven't run a single RCT on anything. Why is this?

/ May 12, 2022
Ivermectin repurposing

Science-based medicine isn’t just for CAM. The case of ivermectin shows that it never was.

Another large randomized controlled trial for ivermectin showed no efficacy for the early treatment of COVID-19. This is not a surprise to science-based medicine advocates. Here's why the story of ivermectin shows that SBM isn't just for "complementary and alternative medicine" (CAM) —and never was.

/ April 4, 2022
Ivermectin repurposing

Ivermectin: The acupuncture of COVID-19 treatments

As high-quality evidence increasingly and resoundingly shows that ivermectin does not work against COVID-19, advocates are doing what acupuncture advocates do: Turning to lower quality "positive" studies to claim incorrectly that their favorite ineffective treatment actually does "work".

/ March 21, 2022

The Yoga RCT

Back in December, 2020, Chief Scientist for the WHO Dr. Soumya Swaminathan tweeted about a study that suggested yoga helped improve various blood markers in people with diabetes. However, a major flaw prevents the study from being rigorous enough to believe its conclusions.

/ June 20, 2021

Ian Harris on “Surgery, the Ultimate Placebo”

Ian Harris explains that more than half of commonly performed surgical operations may be placebos. Adequate studies using a blinded control group are essential.

/ October 27, 2020

Vitamin D supplements do not reduce the risk of depression

A newly-published randomized controlled trial finds vitamin D supplementation has no effect on depression. This adds to the long list of medical conditions for which vitamin D supplementation has turned out to be ineffective.

/ August 6, 2020