Donald Trump versus the FDA: Is the standard of evidence for drug approval actually too low rather than too high?
All of the candidates being considered by President Trump for FDA Commissioner believe that the FDA is too strict in its standards for approving new drugs. In a commentary in Nature last week, two bioethicists argued that, at least in terms of preclinical data, the standard of evidence is actually too low. Which is correct?
“Detox”: Ritual purification masquerading as medicine and wellness
If the "central dogma" of alternative medicine is that wishing makes it so, one of the most important of the other organizing dogmas of alternative medicine is that "toxins," whether they come from inside or outside, are making us sick and that we can't be healthy until we "detoxify." This is far more a religious belief than a science-based one.
How reproducible is basic lab research in cancer biology?
Last week, a review of the reproducibility of several highly cited cancer biology papers was published. The results were mixed and demonstrate how difficult reproducing published results can be at times—and how scientists need to do better.
Donald Trump and Peter Thiel vs. the FDA: Be afraid. Be very afraid.
Donald Trump's three most likely picks for FDA Commissioner all favor loosening drug approval standards. Two are cronies of Peter Thiel, of which one believes that the FDA shouldn't require evidence of efficacy, only safety, and the other believes that a "Yelp for drugs" would do a better job than the FDA. The third candidate is a bona fide, honest-to-goodness pharma shill....
The Medical Director of The Cleveland Clinic Wellness Institute spewed antivaccine misinformation last week. Why is anyone surprised?
A social media firestorm erupted over the weekend after Dr. Daniel Neides, Director of The Cleveland Clinic Wellness Institute, posted an article full of antivaccine misinformation. The Cleveland Clinic promptly disavowed it, but shouldn't have been surprised that one of its "integrative medicine" leaders is antivaccine. If you "integrate" medicine that teaches that "toxins" cause disease and "detoxification" is the cure, antivaccine...
Myths integrative medicine sells us: “We never advocate alternative medicine without conventional medicine”
"Integrative medicine" (IM) effectively integrates quackery with real medicine. The main talking point by advocates of IM meant to deflect this criticism is that IM practitioners always use alternative medicine with conventional medicine and never advocate the use of alternative medicine alone. A new book by a prominent advocate of IM suggests that this talking point is at best self-delusion among academics...
In the tradition of Chairman Mao, traditional Chinese medicine gets a new boost by the Chinese government
Despite a lack of evidence for its efficacy and safety, traditional Chinese medicine (TCM) has made major inroads into US medical centers, both academic and community. I've told the story of how Chairman Mao Zedong created the myth of TCM and promoted it to credulous Westerners to facilitate the "integration" of TCM and "Western medicine." Over the holiday break, I learned that...
Son of (the unethical and unscientific) Trial To Assess Chelation Therapy rears its ugly head to the tune of $37 million
First, the NCCIH and NHLBI spend $30 million on a clinical trial of quackery for cardiovascular disease that produces predictably negative to at best equivocal results. Then that result, apparently, is enough to justify wasting another $37 million on a followup study—while dozens of other deserving studies go unfunded. Meanwhile STAT News lionizes the principal investigator of both trials as a brave...
Oh, look. Naturopathic oncologists are pretending that theirs is a real medical specialty again.
Naturopaths labor under the delusion that theirs is a real medical specialty. It is not, and never will be. Nothing shows that better than when a bunch of naturopaths get together to examine the state of their specialty. Unfortunately for them, if it quacks like a duck...
Can the mind really heal the body? The false narrative of placebo “healing” revisited
Placebo effects are inextricably bound to the question of whether the alternative medicine modalities that are being “integrated” into medicine actually have any useful therapeutic effects or not; i.e., whether they are merely placebos. Here, I examine an article in National Geographic that peddles the false narrative that placebo effects have real "healing" powers against diseases like Parkinson's disease.