Results for: clinical trials
Science Based Satire: We Need Randomized Controlled Clinical Trials of SARS-CoV-2
Before we make any more decisions regarding SARS-CoV-2, we urgently need to conduct large, long-term RCTs of it. I am astonished this is controversial in the medical community.
To unblind or not to unblind? That is the question about clinical trials of COVID-19 vaccines
Antivaccine alternative health tycoon Joe Mercola claims that the unblinding of participants in the clinical trials of Moderna and Pfizer COVID-19 vaccines was intended to "blow up the trials" and undermine the science, making it impossible ever to identify long term adverse events. What he's really doing is deceptively oversimplifying complex ethical and scientific issues surrounding these trials in the middle of...
For-profit stem cell clinics, universities, and “pay-to-play” clinical trials for autism
Stem cell therapies show great promise, but as yet the vast majority of that promise has not been validated in rigorous clinical trials. Unfortunately, for-profit stem cell clinics are running clinical trials that require patients to pay to be part of it. These trials are not rigorous. Even more unfortunately, it appears that some universities are also running "pay-to-play" clinical trials that...
Cell phones and cancer: random chance in clinical trials
The full results of the National Toxicology Program's study of cell phones and cancer are finally in. They are somewhat complicated, but ultimately do not support the idea that cell phones can cause cancer.
Reporting results from clinical trials is vital for science-based medicine
Clinical trials must report on their outcomes, irrespective their results. Doctors and their patients need all the information, not just the good news stories, to make informed decisions.
WHO Statement on Reporting Clinical Trials
The World Health Organization (WHO) has recently released a new position statement on mandatory reporting of all interventional clinical trials. This is a positive step in the trend towards higher quality and greater transparency in clinical trials. The underlying ethical concept here is that the public has a right to data that results from experimentation on humans. The researchers do not ethically...
Clinical trials of homeopathy versus “respect for science”
A few months ago, Steve Novella and I published an article in Trends in Molecular Medicine entitled “Clinical trials of integrative medicine: testing whether magic works?” It was our first foray together into publishing commentary about science-based medicine versus evidence-based medicine, using a topic that we’ve both written extensively about over the years on this blog and our respective personal blogs. Specifically,...
Do doctors pay attention to negative randomized clinical trials?
We at the Science-Based Medicine blog believe that all medicine, regardless of where it comes from, should be held to a single science-based standard with regards to efficacy, effectiveness, and safety. We tend to focus primarily on “complementary and alternative medicine” (CAM), now more commonly known as “integrative medicine,” because (1) we believe it to be undermining the scientific basis of medicine...
Clinical trials of integrative medicine: testing whether magic works?
I just thought that I’d take the editor’s (and, speaking for Steve, the founder’s) prerogative to promote our own efforts. Regular readers of SBM are familiar with our message with respect to randomized clinical trials of highly implausible “complementary and alternative medicine” treatments, such as homeopathy or reiki. Well, believe it or not, Steve and I managed to get a commentary...
The Center for Inquiry weighs in on the FDA’s mishandling of Stanislaw Burzynski’s clinical trials
The Center for Inquiry points out how what Stanislaw Burzynski is doing corrupts the clinical trial process and harms patients.