Irreversible Damage, a controversial 2020 book by Abigail Shrier, has enjoyed renewed attention in the last several weeks. Shrier appeals to her audience’s emotions by voicing their deepest fears to create uproar against an already marginalized community. The claims presented do not meet scientific rigor, yet have been praised and upheld by many, effectively pushing back against equal rights for gender minorities, and, more specifically, denying equitable healthcare for trans youth. This two-part review is based in a framework of evidence-based research and healthcare best practices to address, analyze, and dismantle Shrier’s arguments. It seeks to elucidate the historical and current medicalization of trans identities, present the nidus of widely-accepted yet debunked beliefs, and give context to the research and sources Shrier builds upon for her book.